I型胰岛素样生长因子受体在骨髓增生异常综合征克隆细胞中高表达
[The type I insulin-like growth factor receptor highly expressed in clonal cells of myelodysplastic syndromes].
作者信息
He Qi, Li Xiao, Zhang Zheng, Zhang Qing-xia, Yang Lian-ping
机构信息
The Department of Hematology, Shanghai Jiaotong University, Shanghai, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2011 Nov;32(11):744-7.
OBJECTIVE
To probe the expression level of insulin-like growth factor-I receptor (IGF-IR) in malignant clone cells of myelodysplastic syndromes (MDS).
METHOD
The combination of fluorescence in situ hybridization (FISH) and immunochemistry (alkaline phosphatase anti-alkaline phosphatase, APAAP) was used to detect the expression of IGF-IR in the bone marrow cells of 40 MDS patients with abnormal karyotypes.
RESULTS
The average IGF-IR expression level on the clone cells [(84.5 ± 14.2)%] from the MDS cases was markedly elevated compared to the corresponding level on normal cells [(11.4 ± 12.1)%]. And the percentages of malignant clone cells in all 40 MDS cases were significantly correlated with the relevant percentages of IGF-IR positive nucleated cells (r = 0.929, P < 0.01).
CONCLUSIONS
IGF-IR might be taken as a marker of clone cells in MDS for its trait to malignant proliferation.
目的
探讨胰岛素样生长因子-I受体（IGF-IR）在骨髓增生异常综合征（MDS）恶性克隆细胞中的表达水平。
方法
采用荧光原位杂交（FISH）与免疫化学（碱性磷酸酶抗碱性磷酸酶，APAAP）相结合的方法，检测40例核型异常的MDS患者骨髓细胞中IGF-IR的表达。
结果
MDS病例克隆细胞上IGF-IR的平均表达水平[（84.5±14.2）%]明显高于正常细胞上的相应水平[（11.4±12.1）%]。40例MDS病例中恶性克隆细胞的百分比与IGF-IR阳性有核细胞的相关百分比显著相关（r = 0.929，P < 0.01）。
结论
IGF-IR因其恶性增殖特性，可能作为MDS中克隆细胞的标志物。
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