Department of Endocrinology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.
Chin Med J (Engl). 2011 Dec;124(24):4264-8.
The investigations of prevalence and risk factors of peripheral arterial disease (PAD) in type 2 diabetic patients have been carried out in many countries and regions, except for Central China. In this study, we determined the prevalence of PAD in type 2 diabetic patients and the related factors that gave rise to increasing of the risk of PAD development in Wuhan, China.
The study enrolled 2010 patients aged 60 years and older who were regularly visiting the Central Hospital of Wuhan that is a public hospital from 2005 to 2010, where all residents of the city were offered the medical services. PAD was defined as an ankle-brachial index < 0.90 in either leg. To evaluate the role of various risk factors in PAD development, uniformed interviews, clinical examinations and laboratory investigation of all of participants were performed in this study. The correlation between potential risk factors and PAD was analyzed.
In Wuhan, the prevalence rate of PAD was 24.1% in elderly diabetic patients. Totally, 291 patients with PAD had at least one weak but not absent dorsalis pedis pulse in both feet, while 541 patients without PAD showed this way. At least one absent dorsalis pedis pulse was found in 192 patients with PAD as well as 10 patients without PAD. The results of multivariate regression analysis suggested that the age, smoking history, hypertension, diabetic neuropathy and macroangiopathy gave rise to significant increase of PAD development in type 2 diabetic diseases.
The prevalence of PAD in elderly patients with type 2 diabetes in Wuhan was close to the prevalence that was reported in other regions of China and other Asian countries. Control of the related risk factors and early diagnosis of PAD may play a role in PAD prevention and improving prognosis.
除了中国中部地区，许多国家和地区都对 2 型糖尿病患者外周动脉疾病（PAD）的患病率和危险因素进行了调查。在本研究中，我们确定了中国武汉 2 型糖尿病患者 PAD 的患病率以及导致 PAD 发展风险增加的相关因素。
本研究纳入了 2010 名年龄在 60 岁及以上的患者，他们定期在武汉中心医院就诊，该医院是一家公立医院，服务于全市居民。PAD 定义为双侧踝肱指数<0.90。为了评估各种危险因素在 PAD 发展中的作用，对所有参与者进行了统一的访谈、临床检查和实验室检查。分析了潜在危险因素与 PAD 的相关性。
在武汉，老年糖尿病患者 PAD 的患病率为 24.1%。共有 291 例 PAD 患者双脚均有至少一处足背动脉搏动减弱但未消失，而 541 例无 PAD 患者则无此表现。192 例 PAD 患者和 10 例无 PAD 患者至少有一处足背动脉搏动消失。多因素回归分析结果表明，年龄、吸烟史、高血压、糖尿病神经病变和大血管病变使 2 型糖尿病患者 PAD 的发生显著增加。
武汉老年 2 型糖尿病患者 PAD 的患病率与中国其他地区和其他亚洲国家的报道相近。控制相关危险因素和早期诊断 PAD 可能对 PAD 的预防和改善预后具有重要作用。
