Department of Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning 110004, China.
Chin Med J (Engl). 2011 Dec;124(24):4372-5.
Gastrointestinal stromal tumor (GIST) represents the most common intramural mesenchymal tumor of the gastrointestinal tract, but the synchronous occurrence of GIST in the stomach and gynecological cancer is rare. We present a unique case of a 56-year-old female patient who was diagnosed with the synchronous development of GIST and an isolated parenchymal splenic metastasis of ovarian cancer. She underwent a wide local excision of gastric lesions with splenectomy. A morphological (histological and immunohistochemical) study established a spindle-cell type of gastrointestinal tumor that expressed CD117, and a parenchymal recurrence of ovarian papillary serous adenocarcinoma. The patient has remained alive and disease-free for 30 months since the last operation. A small GIST concomitant with an isolated parenchymal splenic metastasis of ovarian cancer is rarely encountered. The coexistence of GIST with other malignancies constitutes an intriguing oncologic model. Surgeons are advised to be alert against possible primary GIST accompanying other neoplasms.
胃肠道间质瘤（GIST）是胃肠道最常见的壁内间叶性肿瘤，但胃和妇科恶性肿瘤同时发生 GIST 较为罕见。我们报告了 1 例独特的 56 岁女性患者，该患者同时发生 GIST 和卵巢癌孤立性实质脾转移。患者接受了胃病变广泛局部切除术和脾切除术。形态学（组织学和免疫组织化学）研究确立了胃肠道梭形细胞肿瘤，表达 CD117，且为卵巢乳头状浆液性腺癌实质复发性肿瘤。自最后一次手术以来，患者已经无病生存 30 个月。伴有卵巢癌孤立性实质脾转移的小 GIST 很少见。GIST 与其他恶性肿瘤共存构成了一种有趣的肿瘤模型。外科医生应警惕可能存在伴随其他肿瘤的原发性 GIST。
