促黄体生成素释放激素（LHRH）及其类似物对妊娠大鼠卵巢功能的抑制作用。

Suppression of ovarian function by LHRH and its analogues in pregnant rats.

Yoshinaga K

Adv Exp Med Biol. 1979;112:729-34. doi: 10.1007/978-1-4684-3474-3_81.

Abstract

LHRH and its analogues, when infused continuously at the doses that inhibit ovum implantation, reduced serum concentration of progesterone in pregnant rats. The progesterone concentration fell between Days 3 and 4 of pregnancy in rats treated with LHRH and Analogue I (Des-Gly10-LHRH-ethylamide), but fell between Days 4 and 5 in rats treated with Analogue II [Des-Gly10-(D-Ala6)-LHRH-ethylamide]. 2. Ovarian LH/hCG receptor levels were markedly reduced in rats treated with LHRH and its analogues in the first week of pregnancy. 3. Continuous infusion of LH to pregnant rats did not reduce the serum concentration of progesterone even with the highest dose that inhibited implantation. Interruption of pregnancy by LH appears to be due to excessive secretion of estrogen as indicated by uterine swellings, presence of large follicles in the ovaries, and absence of free blastocysts in the uterine lumen. Thus, the antifertility effects of LHRH and its analogues were not reproduced by LH administration.

摘要

当以抑制卵子着床的剂量持续输注时，促性腺激素释放激素（LHRH）及其类似物可降低妊娠大鼠血清中的孕酮浓度。在用LHRH和类似物I（去甘氨酸10 - LHRH - 乙酰胺）处理的大鼠中，孕酮浓度在妊娠第3天至第4天下降，但在用类似物II [去甘氨酸10 -（D - 丙氨酸6）- LHRH - 乙酰胺]处理的大鼠中，孕酮浓度在第4天至第5天下降。2. 在妊娠第一周用LHRH及其类似物处理的大鼠中，卵巢促黄体生成素/人绒毛膜促性腺激素（LH/hCG）受体水平显著降低。3. 即使以抑制着床的最高剂量向妊娠大鼠持续输注LH，也不会降低血清孕酮浓度。LH导致的妊娠中断似乎是由于雌激素分泌过多，表现为子宫肿胀、卵巢中有大卵泡以及子宫腔内无游离胚泡。因此，给予LH不能重现LHRH及其类似物的抗生育作用。