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与传统后神经切除术相比,鼻后神经外周分支切除术治疗重度变应性鼻炎的疗效观察

Resection of peripheral branches of the posterior nasal nerve compared to conventional posterior neurectomy in severe allergic rhinitis.

作者信息

Kobayashi Taisuke, Hyodo Masamitsu, Nakamura Koshiro, Komobuchi Hayato, Honda Nobumitsu

机构信息

Department of Otolaryngology, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, Japan.

出版信息

Auris Nasus Larynx. 2012 Dec;39(6):593-6. doi: 10.1016/j.anl.2011.11.006. Epub 2012 Feb 15.

Abstract

OBJECTIVE

Transnasal resection of the posterior nasal nerve (TRPN) is the surgical procedure for drug therapy-resistant, intractable allergic rhinitis (AR). Submucous inferior turbinectomy also improves nasal symptoms in severe AR. Surgical injury to this peripheral nerve fibre may be the major cause of the decrease in allergic symptoms. During submucous turbinectomy, we have identified the peripheral branches of the posterior nasal nerve in the inferior turbinate and resected them (SRPN). The aim of this study was to evaluate the therapeutic effects of turbinoplasty with SRPN in severe AR.

METHODS

Improvements in subjective symptoms were compared between 13 patients who underwent SRPN with turbinoplasty (Group 1) and 11 who underwent TRPN combined with turbinoplasty and SRPN (Group 2) by retrospective chart review. Pre- and postoperative sneezing, rhinorrhea, and nasal obstruction were evaluated with questionnaires. Postoperative complications and drug therapy before and after surgery were investigated.

RESULTS

All symptoms improved postoperatively in both groups, with no significant differences in the improvements in nasal symptom scores between the groups.

CONCLUSIONS

SRPN combined with submucosal turbinectomy was shown to be a safe, useful, and efficient approach to patients with AR unresponsive to medical therapy. Although this is a short-term study, the results of this study suggest that SRPN represents one of the treatment options for intractable AR.

摘要

目的

经鼻后鼻神经切除术(TRPN)是治疗药物难治性、顽固性变应性鼻炎(AR)的外科手术。下鼻甲黏膜下切除术也可改善重度AR的鼻部症状。该周围神经纤维的手术损伤可能是变应性症状减轻的主要原因。在下鼻甲黏膜下切除术中,我们已识别出下鼻甲内后鼻神经的周围分支并将其切除(SRPN)。本研究的目的是评估SRPN下鼻甲成形术治疗重度AR的疗效。

方法

通过回顾性病历审查,比较13例行SRPN下鼻甲成形术的患者(第1组)和11例行TRPN联合下鼻甲成形术及SRPN的患者(第2组)主观症状的改善情况。通过问卷调查评估术前和术后的打喷嚏、流涕和鼻塞情况。调查术后并发症及手术前后的药物治疗情况。

结果

两组术后所有症状均有改善,两组间鼻部症状评分的改善情况无显著差异。

结论

对于药物治疗无效的AR患者,SRPN联合下鼻甲黏膜下切除术是一种安全、有效且高效的治疗方法。尽管这是一项短期研究,但本研究结果表明,SRPN是顽固性AR的治疗选择之一。

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