Department of Neurology, Brain and Cognitive Sciences, University of Rochester Medical Center, Rochester, NY 14642-0673, USA.
Neurobiol Aging. 2012 Nov;33(11):2551-60. doi: 10.1016/j.neurobiolaging.2011.12.031. Epub 2012 Feb 17.
We assessed the cortical processing of self-movement stimuli in aging and Alzheimer's disease (AD). Our goal was to identify distinguishing effects on neural mechanisms related to driving and navigation. Young (YNC) and older (ONC) normal controls, and early AD patients (EAD) viewed real-world videos and dot motion stimuli simulating self-movement scenes. We recorded visual motion event related potentials (VMERPs) to stimulus motion coherence and speed. Aging delays motion evoked N200s, whereas AD diminishes response amplitudes. Early Alzheimer's disease patients respond to increments in motion coherence, but they are uniquely unresponsive to increments in motion speed that simulate accelerating self-movement. AD-related impairments of self-movement processing may have grave consequences for driving safety and navigational independence.
我们评估了衰老和阿尔茨海默病（AD）中自我运动刺激的皮质处理。我们的目标是确定与驾驶和导航相关的神经机制的区别效应。年轻（YNC）和年长（ONC）正常对照组以及早期 AD 患者（EAD）观看真实世界的视频和模拟自我运动场景的点运动刺激。我们记录了视觉运动事件相关电位（VMERPs）以响应刺激运动的连贯性和速度。衰老会延迟运动诱发的 N200，而 AD 则会降低反应幅度。早期阿尔茨海默病患者对运动连贯性的增加做出反应，但对模拟加速自我运动的运动速度的增加却没有反应。与 AD 相关的自我运动处理受损可能对驾驶安全和导航独立性产生严重后果。
