Jongsma M J, Snijders C J
Sint Lucas Ziekenhuis, Afd. Neurologie, Amsterdam.
Ned Tijdschr Geneeskd. 1990 Oct 27;134(43):2105-6.
A patient treated with valproic acid and phenytoin for complex partial epilepsy developed a stupor at therapeutic serum levels of the anti-epileptic agents. A few days after discontinuation of valproic acid, complete recovery occurred. The pathogenic mechanism involved is still obscure.
一名因复杂部分性癫痫接受丙戊酸和苯妥英治疗的患者,在抗癫痫药物达到治疗性血清水平时出现了昏迷。停用丙戊酸几天后,患者完全康复。其中涉及的致病机制仍不清楚。