Center for Cell-Matrix Research and Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, PO Box 5000, 90014 University of Oulu, Finland.
Int J Biochem Cell Biol. 2012 May;44(5):714-7. doi: 10.1016/j.biocel.2012.01.024. Epub 2012 Feb 8.
Collagen XIII and the homologous collagens XXIII and XXV form a subgroup of type II transmembrane proteins within the collagen superfamily. Collagen XIII consists of a short cytosolic domain, a transmembrane domain and a large extracellular ectodomain, which may be shed into the pericellular matrix. It has been proposed that collagen XIII may function as an adhesion molecule, due to its cellular localization at focal contacts, numerous interactions with basement membrane (BM) and other extracellular matrix (ECM) proteins and expression at various cell-cell and cell-matrix junctions. Recent in vivo studies highlight its involvement in the development, differentiation and maturation of musculoskeletal tissues and vessels and in maintaining tissue integrity.
胶原 XIII 及其同源胶原 XXIII 和 XXV 构成了胶原超家族中 II 型跨膜蛋白的一个亚群。胶原 XIII 由一个短的胞质域、一个跨膜域和一个大的细胞外 ectodomain 组成，ectodomain 可能被分泌到细胞周围基质中。由于其在焦点接触处的细胞定位、与基底膜 (BM) 和其他细胞外基质 (ECM) 蛋白的众多相互作用以及在各种细胞-细胞和细胞-基质连接处的表达，胶原 XIII 可能具有黏附分子的功能。最近的体内研究强调了它在肌肉骨骼组织和血管的发育、分化和成熟以及维持组织完整性中的作用。
