苹婆酸拮抗7-酮胆固醇介导的炎症并抑制脉络膜新生血管形成。
Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization.
作者信息
Huang Jiahn-Dar, Amaral Juan, Lee Jung Wha, Larrayoz Ignacio M, Rodriguez Ignacio R
机构信息
Mechanism of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Biochim Biophys Acta. 2012 Apr;1821(4):637-46. doi: 10.1016/j.bbalip.2012.01.013. Epub 2012 Feb 8.
Abstract
Sterculic acid is a cyclopropene fatty acid with numerous biological activities. In this study we demonstrate that sterculic acid is a potent inhibitor of endoplasmic reticulum (ER) stress and related inflammation caused by 7-ketocholesterol (7KCh). 7KCh is a highly toxic oxysterol suspected in the pathogenesis of various age-related diseases such as atherosclerosis, Alzheimer's disease and age-related macular degeneration. Sterculic acid demonstrated to be 5-10 times more effective than other anti-inflammatory fatty acids at inhibiting 7KCh-mediated inflammatory responses in cultured cells. In vivo, sterculic acid was effective at inhibiting the formation of choroidal neovascularization (CNV) in the laser-injury rat model. Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration.
摘要
苹婆酸是一种具有多种生物活性的环丙烯脂肪酸。在本研究中，我们证明苹婆酸是内质网（ER）应激以及由7-酮胆固醇（7KCh）引起的相关炎症的有效抑制剂。7KCh是一种剧毒的氧化甾醇，被怀疑与各种年龄相关疾病的发病机制有关，如动脉粥样硬化、阿尔茨海默病和年龄相关性黄斑变性。在抑制培养细胞中7KCh介导的炎症反应方面，苹婆酸的效果比其他抗炎脂肪酸高5至10倍。在体内，苹婆酸在激光损伤大鼠模型中能有效抑制脉络膜新生血管（CNV）的形成。我们的数据表明，苹婆酸可能有助于治疗某些形式的年龄相关性黄斑变性中的CNV。
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