Monash Obesity & Diabetes Institute, Monash University, Clayton, Victoria, Australia 3800.
Cell Metab. 2012 Mar 7;15(3):275-6. doi: 10.1016/j.cmet.2012.01.014. Epub 2012 Feb 16.
Hunger elicits feeding behavior by activating Agouti-related peptide (AgRP) neurons. Two recent studies show how fasting, or the hunger hormone ghrelin, promote excitatory glutamate release onto AgRP neurons (Yang et al., 2011) and increase postsynaptic glutamate receptor-mediated drive (Liu et al., 2012).
饥饿通过激活 Agouti 相关肽 (AgRP) 神经元来引发进食行为。最近的两项研究表明,禁食或饥饿激素 ghrelin 如何促进谷氨酸盐在 AgRP 神经元上的兴奋性释放(Yang 等人,2011 年),并增加突触后谷氨酸受体介导的驱动力(Liu 等人,2012 年)。