Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital, Harvard Medical School, Boston, MA, USA.
Bone Marrow Transplant. 2013 Jan;48(1):4-9. doi: 10.1038/bmt.2012.9. Epub 2012 Feb 20.
GVHD remains the most significant complication of hematopoietic SCT, despite advances in HLA matching and the identification of risk various factors. To account for the variation in the incidence and severity of this disease, many genetic association studies have been performed in order to explore the role of immunoregulatory gene polymorphisms. These genes include those that encode cytokines, chemokines, and costimulatory molecules. Polymorphisms in other classes of genes such as those involved in drug metabolism, protein folding, and DNA replication have also been studied. In this review, we address the current knowledge of the role of genetic polymorphisms in GVHD. We also discuss the potential pitfalls inherent in genetic association testing and alternative strategies to address these problems.
移植物抗宿主病仍然是造血干细胞移植后最严重的并发症，尽管在 HLA 匹配和识别各种危险因素方面取得了进展。为了说明这种疾病发病率和严重程度的差异，已经进行了许多遗传关联研究，以探讨免疫调节基因多态性的作用。这些基因包括编码细胞因子、趋化因子和共刺激分子的基因。其他类别的基因，如参与药物代谢、蛋白质折叠和 DNA 复制的基因中的多态性也已被研究。在这篇综述中，我们讨论了遗传多态性在移植物抗宿主病中的作用的现有知识。我们还讨论了遗传关联测试中固有的潜在陷阱，以及解决这些问题的替代策略。
