Brigham and Women's Hospital, Harvard Medical School, Transplantation Research Center, 221 Longwood Avenue, EBRC 312, Boston, MA 02115, USA.
Expert Rev Clin Immunol. 2009 Sep;5(5):523-34. doi: 10.1586/eci.09.44.
Graft-versus-host disease (GVHD) remains a significant complication that greatly enhances morbidity and mortality associated with hematopoietic stem cell transplantation. Key immunoregulatory molecules have been implicated in the pathogenesis of GVHD, but the mechanisms by which these molecules affect the incidence and severity of GVHD have not been fully elucidated. The effects of genetic polymorphisms in immunoregulatory molecules, including cytokines, costimulatory and adhesion molecules, pharmacogenes and growth factors, have been shown to play a central role in GVHD. The results of these polymorphism studies contribute to the identification of predictive risk factors for GVHD based on individual polymorphism makeup. This review summarizes investigations of genetic polymorphisms in immunoregulatory molecules significantly associated with GVHD over the last 5 years.
移植物抗宿主病（GVHD）仍是一个重要的并发症，极大地增加了与造血干细胞移植相关的发病率和死亡率。关键的免疫调节分子已被牵连到 GVHD 的发病机制中，但这些分子影响 GVHD 的发生率和严重程度的机制尚未完全阐明。免疫调节分子（包括细胞因子、共刺激和黏附分子、药物基因和生长因子）中的遗传多态性的影响已被证明在 GVHD 中起核心作用。这些多态性研究的结果有助于根据个体多态性组成确定 GVHD 的预测风险因素。这篇综述总结了过去 5 年中与 GVHD 显著相关的免疫调节分子的遗传多态性的研究。
