Department of Chemistry, The Ohio State University, 100 W, 18th Ave, Columbus, OH 43210, USA.
Chem Commun (Camb). 2012 Mar 25;48(25):3118-20. doi: 10.1039/c2cc17377h. Epub 2012 Feb 16.
A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.
一种针对丙型肝炎病毒（HCV）内部核糖体进入位点（IRES）RNA 茎环 IIb 的催化金属药物表现出类似酶的转化率，其 K(M)为 0.85 μM，k(cat)为 0.53 min(-1)，Cu·GGHYrFK-amide（1-Cu）的转化率数为 31.9，在 HCV 细胞复制子测定中产生 0.58 μM 的抗病毒活性（IC(50)）。
Zotero 插件