Anjomshoa Marzieh, Amirheidari Bagher
Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Coord Chem Rev. 2022 May 1;458:214417. doi: 10.1016/j.ccr.2022.214417. Epub 2022 Feb 5.
Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.
尽管现代药物在治疗癌症、微生物感染和病毒性疾病方面有广泛而迅速的发现，但这些疾病仍然是全球主要的健康问题。为了从天然核酸酶以及诸如博来霉素家族等金属肽抗生素的治疗潜力中获取灵感，可以引入具有促进DNA/RNA切割并最终影响细胞生物学过程能力的人工金属核酸酶作为一类新的治疗候选物。金属配合物可被视为人工金属剪刀的主要类别之一，其能够促使核酸链断裂。因此，全球的生物学家、无机化学家以及药物无机化学家一直在设计、合成和评估作为人工金属剪刀的金属配合物的生物学特性。在这篇综述中，我们试图突出最近关于类核酸酶金属剪刀及其潜在治疗应用的研究。鉴于当前的新冠疫情，人类对新疗法的需求比以往任何时候都更加凸显。因此，具有切割入侵病毒病原体RNA潜力的类核酸酶金属剪刀值得首要关注。
