School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea.
Opt Lett. 2012 Feb 15;37(4):614-6. doi: 10.1364/OL.37.000614.
We propose an intrinsic optical method for in vivo neural recording using optic fiber-based surface plasmon resonance (SPR) phenomena. The fiber-based SPR method is electrical artifact free, labeling free, and feasible for a portable system compared with conventional in vivo neural recording systems. We simultaneously detected SPR signals and electrical neural activity from the rat somatosensory cortex evoked by electrical stimulation on the forepaw. Pharmacological analysis using a voltage-gated sodium channel blocker confirmed the neural origins of the optical signals. This fiber-based SPR system promises the enhanced ability to record in vivo neural activity for the investigation of neurons and their networks.
我们提出了一种利用光纤表面等离子体共振（SPR）现象进行体内神经记录的固有光学方法。与传统的体内神经记录系统相比，基于光纤的 SPR 方法无电伪迹、无标记且适用于便携式系统。我们同时检测了电刺激前爪引起的大鼠体感皮层的 SPR 信号和电神经活动。使用电压门控钠通道阻滞剂进行的药理学分析证实了光学信号的神经起源。这种基于光纤的 SPR 系统有望增强记录体内神经活动的能力，从而用于研究神经元及其网络。
