Tamaji Ai, Iwamoto Kunihiro, Kawamura Yukiko, Takahashi Masahiro, Ebe Kazutoshi, Kawano Naoko, Kunimoto Shohko, Aleksic Branko, Noda Yukihiro, Ozaki Norio
Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Nagoya, Aichi, Japan.
Hum Psychopharmacol. 2012 May;27(3):329-33. doi: 10.1002/hup.2220. Epub 2012 Feb 17.
Serum brain-derived neurotrophic factor (BDNF) levels are reduced in depressed patients, and successful antidepressant treatment leads to increases in BDNF levels. However, little is known about how psychotropic drugs affect the mechanism of the human response to mental stress. We investigated the influence of psychotropic drugs on plasma BDNF levels under mental stress using a driving simulator (DS) task.
Fourteen healthy male volunteers received one of four drugs, diazepam (5 mg), tandospirone (20 mg), paroxetine (10 mg), and matched placebo, in a double-blind, crossover manner. Subjects were asked to perform the DS task 4 h post-dosing. Plasma BDNF levels were measured before and after the DS task.
Plasma BDNF levels under the placebo, diazepam, and tandospirone conditions significantly decreased after the DS task compared with before the task. Conversely, no significant differences in plasma BDNF levels were detected under the paroxetine condition.
As these three psychotropic drugs have differential effects on plasma BDNF levels under mental stress after 4 h post-dosing, antidepressants, unlike anxiolytics, might have a prompt positive effect on the mental stress response.
抑郁症患者血清脑源性神经营养因子（BDNF）水平降低，而成功的抗抑郁治疗会导致BDNF水平升高。然而，关于精神药物如何影响人类对精神压力的反应机制知之甚少。我们使用驾驶模拟器（DS）任务研究了精神药物在精神压力下对血浆BDNF水平的影响。
14名健康男性志愿者以双盲、交叉方式接受四种药物之一，即地西泮（5毫克）、坦度螺酮（20毫克）、帕罗西汀（10毫克）和匹配的安慰剂。受试者在给药后4小时被要求执行DS任务。在DS任务前后测量血浆BDNF水平。
与任务前相比，安慰剂、地西泮和坦度螺酮条件下的血浆BDNF水平在DS任务后显著降低。相反，在帕罗西汀条件下未检测到血浆BDNF水平有显著差异。
由于这三种精神药物在给药后4小时对精神压力下的血浆BDNF水平有不同影响，与抗焦虑药不同，抗抑郁药可能对精神压力反应有迅速的积极作用。
