Sun Yong-Mei, Yang Jian-Zhen, Sun Hua-Ying, Ma Yuan-Ye, Wang Jian-Hong
Chinese Academy of Sciences, Kunming, China.
Dongwuxue Yanjiu. 2012 Feb;33(1):14-8. doi: 10.3724/SP.J.1141.2012.01014.
The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.
由于吗啡具有耐受性、依赖性和成瘾性，其在临床上用于减轻疼痛的应用受到限制。在本研究中，通过注射递增剂量（5、10、15、20mg/kg体重，持续7天）的吗啡，树鼩（中缅树鼩）产生了吗啡耐受性和慢性吗啡依赖性。同时，还发现了纳洛酮（1.25mg/kg体重）诱导的条件性位置厌恶（CPA）和戒断症状。慢性吗啡依赖性树鼩模型可用于未来研究戒断症状并筛选潜在的减轻戒断症状的药物。
