向大鼠脑桥网状结构微量注射卡巴胆碱诱导的僵住症。

Catalepsy induced by carbachol microinjected into the pontine reticular formation of rats.

作者信息

Elazar Z, Paz M

机构信息

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.

出版信息

Neurosci Lett. 1990 Jul 31;115(2-3):226-30. doi: 10.1016/0304-3940(90)90459-m.

DOI:10.1016/0304-3940(90)90459-m

PMID:2234502

Abstract

Rats were implanted stereotaxically with permanent guide tubes aimed at the pontine reticular formation. Carbachol was microinjected in the awake, freely moving rats. Catalepsy was evaluated with the horizontal bar test. Intense and long-lasting, dose-dependent catalepsy was observed following microinjections of 2-8 micrograms of carbachol. Pretreatment with intraperitoneally administered scopolamine significantly reduced the cataleptogenic effect of carbachol. These results show that the pontine reticular formation is part of the neuroanatomical substrate of catalepsy induced by cholinergic drugs.

摘要

将永久性导管立体定向植入大鼠脑桥网状结构。在清醒、自由活动的大鼠中微量注射卡巴胆碱。用横杆试验评估僵住症。微量注射2 - 8微克卡巴胆碱后，观察到强烈且持久的剂量依赖性僵住症。腹腔注射东莨菪碱预处理可显著降低卡巴胆碱的致僵住症作用。这些结果表明，脑桥网状结构是胆碱能药物诱导僵住症的神经解剖学基础的一部分。