Diskapi Education and Research Hospital, Department of Haematology, Ankara, Turkey.
J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):259-64. doi: 10.1177/1470320312437070. Epub 2012 Feb 16.
Angiotensin converting enzyme (ACE) is a circulating enzyme that participates in the body's renin-angiotensin system (RAS) and is localized on the endothelial cell surface in the lung and other vascular beds. It catalyses the conversion of decapeptide angiotensin I to octapeptide angiotensin II. In the present study, we aimed to analyse the possible relationship between the levels of ACE in the context of RAS in multiple myeloma (MM) pathogenesis.
The study was conducted on 25 MM patients (13 males, 12 females; median age 66 years, range 47-88) and 20 healthy controls. The clinical features of MM patients including demographics and laboratory findings were summarized. Serum ACE levels were measured by using commercially available kits.
The serum ACE levels of MM patients and controls were 32.60±20.26 and 15.35±6.47 respectively. Serum ACE levels were significantly higher in MM patients compared with control groups (p<0.001).
Being an important component of RAS, circulating ACE might be associated with clonal proliferation of malignant plasma cells in the bone marrow microenvironment. Identification of the pathobiological activity of the local RAS in MM would enlighten the biologic basis and clinical management of haematologic disorders.
血管紧张素转换酶（ACE）是一种循环酶，参与人体肾素-血管紧张素系统（RAS），定位于肺和其他血管床的内皮细胞表面。它催化十肽血管紧张素 I 转化为八肽血管紧张素 II。在本研究中，我们旨在分析 RAS 背景下 ACE 水平在多发性骨髓瘤（MM）发病机制中的可能关系。
本研究共纳入 25 例 MM 患者（13 例男性，12 例女性；中位年龄 66 岁，范围 47-88 岁）和 20 例健康对照者。总结 MM 患者的临床特征，包括人口统计学和实验室发现。采用商业试剂盒检测血清 ACE 水平。
MM 患者和对照组的血清 ACE 水平分别为 32.60±20.26 和 15.35±6.47。与对照组相比，MM 患者的血清 ACE 水平显著升高（p<0.001）。
作为 RAS 的重要组成部分，循环 ACE 可能与骨髓微环境中恶性浆细胞的克隆增殖有关。鉴定 MM 局部 RAS 的病理生物学活性将阐明血液系统疾病的生物学基础和临床管理。
