Zhanel G G, Nicolle L E, Gin A S, Karlowsky J, Kabani A, Hoban D J
Departments of Medicine and Medical Microbiology and Faculties of Medicine and Pharmacy, University of Manitoba;
Can J Infect Dis. 1998 Nov;9(6):382-6. doi: 10.1155/1998/210742.
To investigate the relationship between ciprofloxacin or imipenem use and antimicrobial resistance in Pseudomonas aeruginosa.
A retrospective review of monthly antimicrobial susceptibility reports for ciprofloxacin (1988 to 1995) and imipenem (1987 to 1995) against P aeruginosa and hospital antimicrobial use records at a tertiary care teaching hospital in Winnipeg, Manitoba. Data were entered into a relational database, R:Base 4.5++, collated, transferred to a spreadsheet and subjected to linear regression analysis. The relationship between ciprofloxacin or imipenem use and resistance was assessed using a Pearson correlation.
Ciprofloxacin-resistant P aeruginosa increased from 1.0% of all isolates in 1988 to 10.0% in 1995. A significant (P=0.05) correlation was demonstrated between the amount of ciprofloxacin use and prevalence of ciprofloxacin-resistant P aeruginosa (r=0.73, P=0.05). Imipenem-resistant P aeruginosa increased from 1.0% of isolates in 1987 to a maximum of 10.4% in 1991, and subsequently decreased to 5.4% in 1995. Imipenem use and the prevalence of imipenem-resistant P aeruginosa were significantly correlated (r=0.85, P=0.014).
Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa.
研究环丙沙星或亚胺培南的使用与铜绿假单胞菌耐药性之间的关系。
回顾性分析在马尼托巴省温尼伯市一家三级护理教学医院中，1988年至1995年期间环丙沙星以及1987年至1995年期间亚胺培南针对铜绿假单胞菌的月度药敏报告，以及医院抗菌药物使用记录。数据录入关系数据库R:Base 4.5++，进行整理，转移至电子表格并进行线性回归分析。使用Pearson相关性评估环丙沙星或亚胺培南的使用与耐药性之间的关系。
对环丙沙星耐药的铜绿假单胞菌在所有分离株中的占比从1988年的1.0%增至1995年的10.0%。环丙沙星的使用量与对环丙沙星耐药的铜绿假单胞菌的流行率之间呈现显著相关性（P=0.05）（r=0.73，P=0.05）。对亚胺培南耐药的铜绿假单胞菌在分离株中的占比从1987年的1.0%增至1991年最高的10.4%，随后在1995年降至5.4%。亚胺培南的使用与对亚胺培南耐药的铜绿假单胞菌的流行率显著相关（r=0.85，P=0.014）。
环丙沙星的使用与铜绿假单胞菌对环丙沙星的耐药性直接相关，亚胺培南的使用与铜绿假单胞菌对亚胺培南的耐药性直接相关。
