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2,6-双（4-甲氧基苯基）-1,3-二甲基哌啶-4-酮O-苄基肟

2,6-Bis(4-meth-oxy-phen-yl)-1,3-dimethyl-piperidin-4-one O-benzyl-oxime.

作者信息

Park Dong Ho, Ramkumar V, Parthiban P

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o524. doi: 10.1107/S1600536812002140. Epub 2012 Jan 25.

DOI:10.1107/S1600536812002140
PMID:22347121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3275265/
Abstract

The central ring of the title compound, C(28)H(32)N(2)O(3), exists in a chair conformation with an equatorial disposition of all the alkyl and aryl groups on the heterocycle. The para-anisyl groups on both sides of the secondary amino group are oriented at an angle of 54.75 (4)° with respect to each other. The oxime derivative exists as an E isomer with the methyl substitution on one of the active methyl-ene centers of the mol-ecule. The crystal packing features weak C-H⋯O inter-actions.

摘要

标题化合物C(28)H(32)N(2)O(3)的中心环呈椅式构象，杂环上所有烷基和芳基均处于平伏位置。仲氨基两侧的对甲氧基苯基相对于彼此呈54.75 (4)°的夹角。肟衍生物以E异构体形式存在，分子中一个活性亚甲基中心上有甲基取代。晶体堆积具有弱的C—H⋯O相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b9/3275265/52e0054c9725/e-68-0o524-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b9/3275265/6750b2e54819/e-68-0o524-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b9/3275265/52e0054c9725/e-68-0o524-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b9/3275265/6750b2e54819/e-68-0o524-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b9/3275265/52e0054c9725/e-68-0o524-fig2.jpg

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Synthesis of polyfunctionalized piperidone oxime ethers and their cytotoxicity on HeLa cells.哌啶酮肟醚的多功能化合成及其对 HeLa 细胞的细胞毒性。
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A short history of SHELX.
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（E）-3-甲基-2,6-二苯基-哌啶-4-酮 O-（3-甲基苯甲酰基）肟
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Methyl ({[(4E)-1,3-dimethyl-2,6-di-phenyl-piperidin-4-yl-idene]amino}-oxy)acetate.甲基({[(4E)-1,3-二甲基-2,6-二苯基-哌啶-4-亚基]氨基}-氧基)乙酸酯
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[(4E)-1-Methyl-2,6-diphenyl-3-(propan-2-yl)piperidin-4-yl-idene]amino 3-methyl-benzoate.[(4E)-1-甲基-2,6-二苯基-3-(丙烷-2-基)哌啶-4-亚基]氨基 3-甲基苯甲酸酯
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