缺氧的分子成像：探针设计与应用策略
Molecular Imaging of Hypoxia: Strategies for Probe Design and Application.
作者信息
Apte Sandeep, Chin Frederick T, Graves Edward E
机构信息
Molecular Imaging Program at Stanford (MIPS), Department of Radiation of Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
出版信息
Curr Org Synth. 2011 Aug;8(4):593-603. doi: 10.2174/157017911796117179.
Abstract
Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.
摘要
肿瘤缺氧是一种负面预后因素，其精确成像对于治疗规划具有重要意义。本综述总结了用于通过正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）和荧光成像等多种技术对缺氧进行成像的探针设计的各种策略。还讨论了一些用于临床前和临床成像的重要探针的合成及其在缺氧状态下的结合机制。
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