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3 型青年发病成人型糖尿病患者的胰腺原发性淋巴瘤。

Primary pancreatic lymphoma in a patient with maturity onset diabetes of the young type 3.

机构信息

Istituto di Ematologia, Università Cattolica del Sacro Cuore, Roma, Italy.

出版信息

Mediterr J Hematol Infect Dis. 2012;4(1):e2012005. doi: 10.4084/MJHID.2012.005. Epub 2012 Jan 18.

DOI:10.4084/MJHID.2012.005
PMID:22348187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3279320/
Abstract

Primary pancreatic lymphoma (PPL) is an extremely rare disease which occurs in pancreas, accounts for less than 1% of extra-nodal malignant lymphomas and 0,5% of cases of pancreatic masses. We report the case of PPL in a 15 year-old boy suffering from Maturity Onset Diabetes of the Young type 3 (MODY3) diagnosed at the age of 1 year.

摘要

原发性胰腺淋巴瘤（PPL）是一种极其罕见的疾病，发生于胰腺，占结外恶性淋巴瘤的不到 1%，胰腺肿块的 0.5%。我们报告了一例 15 岁男孩的 PPL 病例，该男孩在 1 岁时被诊断为 3 型年轻发病的成年型糖尿病（MODY3）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ea/3279320/9ecb6029cbc8/mjhid-4-1-e2012005f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ea/3279320/f03ed2f4dca8/mjhid-4-1-e2012005f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ea/3279320/9ecb6029cbc8/mjhid-4-1-e2012005f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ea/3279320/f03ed2f4dca8/mjhid-4-1-e2012005f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ea/3279320/9ecb6029cbc8/mjhid-4-1-e2012005f2.jpg

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本文引用的文献

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Primary pancreatic lymphoma.原发性胰腺淋巴瘤
Tumori. 2009 Mar-Apr;95(2):156-9. doi: 10.1177/030089160909500205.
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Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.肝细胞核因子1α（Hnf1α，即MODY3）控制组织特异性转录程序，并对胰岛和肝脏中的细胞生长发挥相反作用。
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Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype.意大利患有青少年发病的成年型糖尿病（MODY）表型家族中GCK和HNF1A基因的新型突变。
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Diabetes and risk of Non-Hodgkin's lymphoma: a meta-analysis of observational studies.糖尿病与非霍奇金淋巴瘤风险：观察性研究的荟萃分析
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Bi-allelic inactivation of TCF1 in hepatic adenomas.肝腺瘤中TCF1的双等位基因失活。
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N Engl J Med. 2001 Sep 27;345(13):971-80. doi: 10.1056/NEJMra002168.
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Hum Pathol. 2001 Jul;32(7):741-5. doi: 10.1053/hupa.2001.25594.