Augustine Titus
Manchester Royal Infirmary, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
J Ren Care. 2012 Feb;38 Suppl 1:115-24. doi: 10.1111/j.1755-6686.2012.00269.x.
Simultaneous Pancreas and Kidney (SPK) transplantation in the 21st century is a proven therapeutic intervention for diabetes with renal failure. Although it is a major invasive procedure, successful transplantation leads to an overall improvement in the quality of life of the recipient, freedom from insulin and dialysis, along with stabilisation and improvement in several of the multi-system complications associated with long-term diabetes. It is also associated with improved longevity when compared to diabetics who have had a kidney transplant alone. The combined transplant could be considered a curative procedure albeit at the expense of long-term immunosuppression. In essence, successful SPK transplantation may be considered the gold standard against which all other therapeutic interventions may be measured in diabetes with end-stage renal failure.
21世纪的胰肾联合移植（SPK）是一种已被证实的针对糖尿病合并肾衰竭的治疗手段。尽管这是一项重大的侵入性手术，但成功的移植会使受者的生活质量全面提高，摆脱胰岛素和透析，同时稳定并改善一些与长期糖尿病相关的多系统并发症。与仅接受肾移植的糖尿病患者相比，它还能延长寿命。联合移植可被视为一种治愈性手术，尽管要付出长期免疫抑制的代价。从本质上讲，成功的SPK移植可被视为金标准，据此可衡量糖尿病终末期肾衰竭的所有其他治疗手段。
