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[抽动秽语综合征的遗传学]

[The genetics of Gilles de la Tourette syndrome].

作者信息

Bertelsen Birgitte, Melchior Linea, Debes Nanette Mol, Skov Liselotte, Brøndum-Nielsen Karen, Tümer Zeynep

机构信息

Center for Anvendt Human Molekylærgenetik, Kennedy Centret, Gl. Landevej 7, 2600 Glostrup, Denmark.

出版信息

Ugeskr Laeger. 2012 Feb 20;174(8):484-7.

Abstract

Knowledge about the aetiology of Gilles de la Tourette syndrome (GTS) is very limited. GTS has a complex mode of inheritance in which both genetic and environmental factors are believed to be involved in disease development. Different approaches to identify GTS associated genes have led to the discovery of several candidate genes. However, none of these has been shown to be major causative genes associated with the development of GTS. Future use of large clinical cohorts and new technologies will hopefully result in the identification of genes associated with GTS.

摘要

关于抽动秽语综合征(GTS)的病因学知识非常有限。GTS具有复杂的遗传模式,其中遗传因素和环境因素都被认为与疾病发展有关。识别与GTS相关基因的不同方法已导致发现了几个候选基因。然而,这些基因中没有一个被证明是与GTS发展相关的主要致病基因。未来使用大型临床队列和新技术有望导致识别出与GTS相关的基因。

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