Tang C, Chan M, Lee J, Hariram J
Department of General Psychiatry, Institute of Mental Health, Singapore.
East Asian Arch Psychiatry. 2010 Dec;20(4):190-2.
Darier's disease, also known as Darier-White disease or keratosis follicularis, is a rare autosomal dominant genodermatosis. Clinical experience has long suggested an association between neuropsychiatric abnormalities and Darier's disease. Although there are no formal epidemiological studies confirming this association, there have been a number of reports of patients with neuropsychiatric manifestations and Darier's disease in the literature. However, most reports have come from Caucasian populations, with limited reports of Darier's disease and its neuropsychiatric associations among Asian populations. This report describes 2 Asian patients presenting with associated schizophrenia and Darier's disease.
毛囊角化病，又称达里埃-怀特病或毛囊角化症，是一种罕见的常染色体显性遗传性皮肤病。长期的临床经验表明，神经精神异常与毛囊角化病之间存在关联。尽管尚无正式的流行病学研究证实这种关联，但文献中有许多关于患有神经精神症状的毛囊角化病患者的报告。然而，大多数报告来自白种人群体，关于亚洲人群中毛囊角化病及其与神经精神关联的报告有限。本报告描述了2例伴有精神分裂症的亚洲毛囊角化病患者。
