Khandekar J D
Ann Clin Lab Sci. 1979 May-Jun;9(3):212-8.
Islet cell tumors produce a spectrum of syndromes. Intensive investigations of these tumors have enhanced our understanding of cellular origin, physiology and biochemistry of the islet hormones. Biochemical studies on the hormones are helpful in the diagnosis and treatment planning of the islet tumors. For example, insulinoma and glucagonoma can be diagnosed more readily by demonstration of proinsulin and proglucagon-like components, respectively, in the blood. Similarly, measurement of vasoactive intestinal polypeptide is not only useful in the diagnosis, but also in the follow-up of patients with pancreatic cholera syndrome. This mini-review examines these and other clinico-biochemical correlates seen in islet tumors.
胰岛细胞瘤可产生一系列综合征。对这些肿瘤的深入研究增进了我们对胰岛激素的细胞起源、生理学和生物化学的理解。对激素的生化研究有助于胰岛肿瘤的诊断和治疗规划。例如，通过分别在血液中检测胰岛素原和胰高血糖素原样成分，可更容易地诊断胰岛素瘤和胰高血糖素瘤。同样，血管活性肠肽的检测不仅有助于诊断，还可用于胰性霍乱综合征患者的随访。本综述探讨了胰岛肿瘤中所见的这些及其他临床生化关联。
