Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Autoimmun Rev. 2012 Sep;11(11):804-5. doi: 10.1016/j.autrev.2012.02.010. Epub 2012 Feb 12.
In 1995, the SLAM-associated protein (SAP) gene was cloned in our laboratory, and patents were subsequently filed in the USA, EU and Canada. In 1998, the SAP gene was shown to be defective in patients with X-linked lymphoproliferative disease. Since this discovery, the gene has been demonstrated to play a significant role in viral protection, cytokine production and life-long immune memory (vaccination). This article reviews the crucial role of SAP in the development of autoimmunity.
1995 年，我们实验室克隆了 SLAM 相关蛋白（SAP）基因，并随后在美国、欧盟和加拿大申请了专利。1998 年，SAP 基因被证明在 X 连锁淋巴组织增生性疾病患者中存在缺陷。自这一发现以来，该基因已被证明在病毒保护、细胞因子产生和终身免疫记忆（疫苗接种）方面发挥着重要作用。本文综述了 SAP 在自身免疫发展中的关键作用。
