Guieu R, Tardy-Gervet M F, Blin O, Pouget J
Laboratoire de Neurobiologie Humaine, U.R.A. C.N.R.S. 372, Centre Scientifique de St. Jérôme, MarseillesFrance Clinique des Maladies du Système Nerveux C.H.U. Timone, MarseillesFrance.
Pain. 1990 Jul;42(1):43-48. doi: 10.1016/0304-3959(90)91090-6.
A patient is described with painful legs and moving toes. The pain had been occurring for more than 15 years, and a variety of therapies had been attempted with only partial, if any, success. Only morphine had succeeded in relieving the pain, but it had to be discontinued to avoid tolerance and dependence. We devised a treatment consisting of transcutaneous electrical nerve stimulation (TENS), vibratory stimulation (VS), and a combination of the two methods (TENS + VS). TENS brought about partial pain relief, but was less effective than VS; dual stimulation (TENS + VS) led to complete alleviation of the pain. Four months later, the patient was applying dual stimulation himself at home and was thus able to maintain complete relief with 3 or 4 weekly sessions. We suggest that dual stimulation results in a large-scale recruitment of large-diameter afferent fibres and may thus set up a powerful inhibitory control of nociception in our patient.
本文描述了一位患有腿部疼痛和脚趾活动异常的患者。疼痛已经持续了15年多,尝试过多种治疗方法,但即便有效果也只是部分缓解。只有吗啡成功缓解了疼痛,但为了避免耐受性和依赖性不得不停药。我们设计了一种治疗方法,包括经皮神经电刺激(TENS)、振动刺激(VS)以及两种方法的联合应用(TENS + VS)。TENS使疼痛得到部分缓解,但效果不如VS;双重刺激(TENS + VS)导致疼痛完全缓解。四个月后,患者在家自行进行双重刺激,通过每周3至4次的治疗能够维持完全缓解。我们认为,双重刺激可大量募集大直径传入纤维,从而可能在我们的患者中建立起对伤害性感受的强大抑制性控制。