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自闭症谱系障碍中重金属的正常浓度。

Normal concentrations of heavy metals in autistic spectrum disorders.

作者信息

Albizzati A, Morè L, Di Candia D, Saccani M, Lenti C

机构信息

Operative Unit Child Neuropsychiatry A.O. San Paolo Hospital, University of Milan, Milan, Italy.

出版信息

Minerva Pediatr. 2012 Feb;64(1):27-31.

Abstract

AIM

Autism is a neurological-psychiatric disease. In the last 20 years we witnessed a strong increase of autism diagnoses. To explain this increase, some scientists put forward the hypothesis that heavy metal intoxication may be one of the causes of autism. The origin of such an intoxication was hypothesised to be vaccines containing thimerosal as antimicrobic preservative. This preservative is mainly made up of mercury. The aim of our research was to investigate the correlation between autism and high biological concentrations of heavy metals.

METHODS

Seventeen autistic patients, between 6 and 16 years old (average: 11.52 DS: 3.20) (15 males and 2 females), were investigated, as well as 20 non autistic subjects from neuropsychiatric service between 6 and 16 years (average: 10.41 DS: 3.20) (15 males and 2 females). In both groups blood, urine and hair samples were analysed trough means of a semiquantitative analysis of heavy metal dosing. The metals analysed were Lead, mercury, cadmium and aluminium, since their build-up may give both neurological and psychiatric symptoms.

RESULTS

The comparison of the mean values of the concentrations between the groups, performed with ANOVA test, has shown no statistically relevant differences.

CONCLUSION

There wasn't correlation between autism and heavy metal concentration.

摘要

目的

自闭症是一种神经精神疾病。在过去20年里,我们目睹了自闭症诊断数量的大幅增加。为了解释这一增长,一些科学家提出假设,认为重金属中毒可能是自闭症的病因之一。这种中毒的源头被推测为含有硫柳汞作为抗菌防腐剂的疫苗。这种防腐剂主要由汞组成。我们研究的目的是调查自闭症与高生物浓度重金属之间的相关性。

方法

对17名6至16岁(平均:11.52;标准差:3.20)的自闭症患者(15名男性和2名女性)以及20名6至16岁(平均:10.41;标准差:3.20)来自神经精神科的非自闭症受试者(15名男性和2名女性)进行了调查。对两组的血液、尿液和头发样本通过重金属定量的半定量分析方法进行分析。所分析的金属为铅、汞、镉和铝,因为它们的蓄积可能导致神经和精神症状。

结果

通过方差分析对两组之间浓度平均值进行比较,结果显示无统计学上的显著差异。

结论

自闭症与重金属浓度之间不存在相关性。

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