Hufendiek Karsten, Hufendiek Katerina, Finkenzeller Thomas, Helbig Horst, Framme Carsten
Department of Ophthalmology, University Medical Center Regensburg, Regensburg, Germany.
Int Ophthalmol. 2012 Apr;32(2):165-9. doi: 10.1007/s10792-012-9525-5. Epub 2012 Feb 16.
An unintentional embolization of retinal arteries is rare and has been documented as a complication after embolization of arteries supplying head and neck tumors. However, occlusion of the central retinal artery with severe loss of vision has never been reported to be a complication from embolization of tumor-supplying ethmoidal branches of the ophthalmic artery. A 40 year-old male patient with a history of right nephrectomy for renal cell carcinoma underwent preoperative radiological embolization of an ethmoidal metastasis after having experienced a life-threatening sinus bleeding. Repeated probing of the ophthalmic artery with an endovascular microcatheter for particle embolization of the tumor-supplying arteries was performed under anticoagulation with heparin. Postoperatively, a standard ophthalmological examination including extended vascular evaluation by angiography was performed. After extended probing of the ophthalmic artery a marked reduction in its blood flow occurred. Despite post-interventional imaging showing persisting perfusion of the central retinal and ciliary arteries, the patient developed complete loss of vision on this side four days later. At this time fundoscopy and fluorescein angiography revealed a recanalized central artery occlusion, while indocyanin angiography showed infarctions of the choroid. Radiological intervention via the ophthalmic artery can result in complete loss of vision, even after limited and transient obstruction of the vessel.
视网膜动脉意外栓塞较为罕见,有文献记载其为头颈部肿瘤供血动脉栓塞后的一种并发症。然而,从未有报道称视网膜中央动脉闭塞并导致严重视力丧失是眼动脉筛窦分支肿瘤供血动脉栓塞的并发症。一名40岁男性患者,有因肾细胞癌行右肾切除术史,在经历危及生命的鼻窦出血后,对筛窦转移灶进行了术前放射栓塞治疗。在肝素抗凝下,使用血管内微导管反复探查眼动脉,以便对肿瘤供血动脉进行颗粒栓塞。术后,进行了包括通过血管造影进行扩展血管评估在内的标准眼科检查。在对眼动脉进行长时间探查后,其血流明显减少。尽管介入后成像显示视网膜中央动脉和睫状动脉持续灌注,但患者在四天后出现了患侧完全失明。此时,眼底镜检查和荧光素血管造影显示中央动脉闭塞再通,而吲哚菁绿血管造影显示脉络膜梗死。即使血管仅有有限的短暂阻塞,经眼动脉的放射介入也可能导致完全失明。