Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Langenbecks Arch Surg. 2012 Apr;397(4):495-505. doi: 10.1007/s00423-012-0916-x. Epub 2012 Feb 15.
Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals.
The preclinical study of pancreatic intraepithelial neoplasia (PanINs) has recently been made possible by the generation of genetically modified animal models, which recapitulate human PanINs and invasive pancreatic cancer on a genetic and histomorphologic level. Very recently, several groups have reported first evidence of chemoprevention of pancreatic cancer.
由于胰腺癌的死亡率接近发病率，只有 1-4%的患者能存活 5 年，因此对高危人群进行化学预防治疗将具有重要意义。
最近，通过生成遗传修饰动物模型，使胰腺上皮内瘤变（PanINs）的临床前研究成为可能，这些模型在遗传和组织形态学水平上重现了人类 PanINs 和侵袭性胰腺癌。最近，有几个研究小组报告了胰腺癌化学预防的初步证据。
