McLintock L M, Turner C M, Vickerman K
Department of Zoology, University of Glasgow.
Parasitology. 1990 Aug;101 Pt 1:49-55. doi: 10.1017/s0031182000079749.
The hypothesis that division of Trypanosoma brucei slender bloodstream forms is dependent upon the availability of a host-derived growth factor has been tested by superimposing challenge doses of slender-form trypanosomes onto preexisting infections at a time during the primary infection when stumpy forms predominated. The challenge populations grew in the doubly-infected mice indicating that depletion of a putative growth factor by the expanding population of the primary infection had not prevented division of the trypanosomes although slight reductions in multiplication rates were observed. This effect was independent of the variable antigen type (VAT) of the trypanosomes and of their stock of origin.
布氏锥虫细长型血流形式的分裂依赖于宿主来源生长因子的可用性这一假说，已通过在初次感染中 stump 形式占主导的时期，将挑战剂量的细长型锥虫叠加到先前存在的感染上来进行了测试。挑战群体在双重感染的小鼠中生长，这表明尽管观察到增殖率略有降低，但初次感染不断扩大的群体对假定生长因子的消耗并未阻止锥虫的分裂。这种效应与锥虫的可变抗原类型（VAT）及其来源种群无关。
