Havton Leif A
Department of Anesthesiology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Methods Mol Biol. 2012;851:185-93. doi: 10.1007/978-1-61779-561-9_13.
Neuropathic pain may develop after a variety of injuries to peripheral nerves and roots. Most injury models have included a direct injury to primary afferent fibers or neurons. Recently, it has been demonstrated that injury to motor fibers in ventral roots may also result in neuropathic pain. A lumbosacral ventral root avulsion injury results in acute and persistent mechanical allodynia, but not thermal hyperesthesia. Interestingly, an acute replantation of the avulsed ventral roots into the spinal cord results in amelioration of the neuropathic pain. A detailed description of this injury and repair model is provided.
神经性疼痛可能在周围神经和神经根受到多种损伤后出现。大多数损伤模型都包括对初级传入纤维或神经元的直接损伤。最近，有研究表明，腰骶部腹侧神经根运动纤维的损伤也可能导致神经性疼痛。腰骶部腹侧神经根撕脱伤会导致急性和持续性机械性异常性疼痛，但不会出现热感觉过敏。有趣的是，将撕脱的腹侧神经根急性再植入脊髓可改善神经性疼痛。本文提供了该损伤和修复模型的详细描述。
