Kohelet D, Usher M, Arbel E, Arlazoroff A, Goldberg M
Department of Neonatology, Assaf Harofeh Medical Center, Zerifin, Israel.
Pediatr Res. 1990 Sep;28(3):232-4. doi: 10.1203/00006450-199009000-00017.
Seven essentially healthy term infants who received gentamicin starting on the 1st day of life for prolonged rupture of membranes and maternal fever were compared with nine healthy term infants to determine whether this drug induces alterations in the auditory pathway. The auditory pathway was studied on the 3rd day of life by analyzing brainstem auditory evoked potentials elicited by a click stimulus presented at the infant's ears. Latencies of components III and V, interval I-III, and interval I-V were significantly prolonged in the gentamicin group, indicating impairment of the central component of the auditory pathway. Peak and trough serum gentamicin levels all fell within the recommended therapeutic range. The study indicates that short course gentamicin therapy in healthy newborn infants can lead to abnormality of auditory function.
将七名从出生第一天起因胎膜早破和母亲发热而接受庆大霉素治疗的基本健康的足月儿与九名健康足月儿进行比较，以确定这种药物是否会引起听觉通路的改变。在出生第三天，通过分析婴儿耳部发出的咔嗒声刺激诱发的脑干听觉诱发电位来研究听觉通路。庆大霉素组中，III和V波的潜伏期、I-III间期和I-V间期均显著延长，表明听觉通路的中枢部分受损。血清庆大霉素的峰值和谷值均在推荐的治疗范围内。该研究表明，健康新生儿短期使用庆大霉素治疗可导致听觉功能异常。
