Kalogeraki Alexandra M, Tamiolakis Dimitrios J, Lagoudaki Eleni D, Papadakis Michael N, Papadakis George Z, Agelaki Sofia I, Stathopoulos Efstathios N, Tzardi Maria N
Department of Pathology-Cytopathology, Medical School, University of Crete, Heraklion, Crete, Greece.
Diagn Cytopathol. 2013 Jul;41(7):654-7. doi: 10.1002/dc.21859. Epub 2012 Feb 20.
Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease.
