Capeding M R, Lazaro J A, Kaneko Y Y
Research Institute for Tropical Medicine, Department of Health, Metro Manila, Philippines.
Pediatr Infect Dis J. 1990 Aug;9(8):570-3. doi: 10.1097/00006454-199008000-00009.
Identifying opportunities to vaccinate eligible children is one way to boost rates of immunization especially in countries with low immunization coverage and where convalescence from infectious illness is a contraindication to vaccination. To determine the safety and immunogenicity of diphtheria-tetanus toxoid-pertussis and oral polio immunization, 210 convalescing infants and children and community controls, comparable image and nutritional status, were studied. Using the pertussis agglutination and poliovirus neutralization tests, quantitative serologic responses were compared in the two study groups. No significant differences in the incidence rates of febrile reactions (23% in controls; 28% in convalescents) of local reactions (92% in controls; 87% in convalescents) and of seroconversion (P greater than 0.05) were noted between the two groups. Our investigation suggests that infants and children convalescing from infectious illnesses can be safely and effectively vaccinated. This study further suggests that hospitalization provides an opportunity to vaccinate such children.
识别为符合条件的儿童接种疫苗的机会是提高免疫接种率的一种方式，尤其是在免疫接种覆盖率较低且传染病康复是接种疫苗禁忌证的国家。为了确定白喉-破伤风类毒素-百日咳疫苗和口服脊髓灰质炎疫苗的安全性和免疫原性，对210名正在康复的婴幼儿及社区对照儿童（具有相似的影像和营养状况）进行了研究。通过百日咳凝集试验和脊髓灰质炎病毒中和试验，比较了两个研究组的定量血清学反应。两组之间在发热反应发生率（对照组为23%；康复组为28%）、局部反应发生率（对照组为92%；康复组为87%）和血清转化方面（P大于0.05）均未发现显著差异。我们的调查表明，正在从传染病中康复的婴幼儿可以安全有效地接种疫苗。这项研究进一步表明，住院治疗为给这类儿童接种疫苗提供了机会。
