Walter E B, Moggio M V, Drucker R P, Wilfert C M
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Pediatr Infect Dis J. 1990 Sep;9(9):632-5.
Children younger than 2 years of age with previous invasive Haemophilus influenzae (Hib) type b disease may not develop protective antibodies to antigens of Hib and may be at risk of developing a second episode of Hib disease. Twenty-three children with prior Hib disease were immunized with Haemophilus b conjugate vaccine (meningococcal protein conjugate). Children 12 to 24 months of age were given one dose of vaccine and children younger than 12 months of age were given 2 doses 2 months apart. Antibody to the polysaccharide capsule of Hib (PRP) was measured by radioimmunoassay. Eighteen children had preimmunization serum antibody concentrations less than 0.150 micrograms/ml. All 18 children responded with greater than 0.150 micrograms/ml of antibody after a single dose of vaccine. Only 1 of the 23 children had a preimmunization serum antibody concentration greater than 1.000 micrograms/ml. Seventeen children ultimately responded with greater than 1.000 micrograms/ml of antibody (P less than 0.0001), concentrations of antibody thought to correlate with protection. Haemophilus b conjugate vaccine (meningococcal protein conjugate) is immunogenic in children with invasive Hib disease. Children younger than 2 years of age with invasive Hib disease should be subsequently immunized with a Hib conjugate vaccine.
曾患侵袭性b型流感嗜血杆菌（Hib）疾病的2岁以下儿童可能无法产生针对Hib抗原的保护性抗体，并有发生第二次Hib疾病的风险。23名曾患Hib疾病的儿童接种了b型流感嗜血杆菌结合疫苗（脑膜炎球菌蛋白结合疫苗）。12至24个月大的儿童接种一剂疫苗，12个月以下的儿童接种两剂，间隔2个月。通过放射免疫测定法检测针对Hib多糖荚膜（PRP）的抗体。18名儿童免疫前血清抗体浓度低于0.150微克/毫升。所有18名儿童在接种一剂疫苗后抗体反应均大于0.150微克/毫升。23名儿童中只有1名免疫前血清抗体浓度大于1.000微克/毫升。17名儿童最终抗体反应大于1.000微克/毫升（P<0.0001），该抗体浓度被认为与保护作用相关。b型流感嗜血杆菌结合疫苗（脑膜炎球菌蛋白结合疫苗）对患侵袭性Hib疾病的儿童具有免疫原性。曾患侵袭性Hib疾病的2岁以下儿童随后应接种Hib结合疫苗。
