• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

B 型肉毒梭菌在连续传代过程中毒力稳定性的研究

Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.

机构信息

Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan.

出版信息

Microbiol Immunol. 2012 May;56(5):338-41. doi: 10.1111/j.1348-0421.2012.00441.x.

DOI:10.1111/j.1348-0421.2012.00441.x
PMID:22352877
Abstract

Proteolytic Clostridium botulinum type B strains were investigated for stability of toxigenicity and bont/b gene upon serial passage. Strains with bont/b gene located on their plasmids showed loss or decrease of toxigenicity during serial passage. Some strains lost the bont/b gene-encoding plasmid. The stability of the plasmids varied between strains.

摘要

研究了具有蛋白水解活性的 B 型肉毒梭菌菌株在连续传代过程中毒力和 bont/b 基因的稳定性。带有位于质粒上的 bont/b 基因的菌株在连续传代过程中显示出毒力的丧失或降低。一些菌株丢失了编码 bont/b 基因的质粒。质粒的稳定性在菌株间有所不同。

相似文献

1
Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.B 型肉毒梭菌在连续传代过程中毒力稳定性的研究
Microbiol Immunol. 2012 May;56(5):338-41. doi: 10.1111/j.1348-0421.2012.00441.x.
2
Complete nucleotide sequence of a plasmid containing the botulinum neurotoxin gene in Clostridium botulinum type B strain 111 isolated from an infant patient in Japan.从日本一名婴儿患者中分离到的 B 型肉毒梭菌 111 株携带的肉毒神经毒素基因的质粒的完整核苷酸序列。
Mol Genet Genomics. 2014 Dec;289(6):1267-74. doi: 10.1007/s00438-014-0887-4. Epub 2014 Aug 23.
3
Proteolytic Clostridium botulinum type B in the gastric content of a patient with type E botulism due to whitefish eggs.一名因食用白鲑鱼卵患E型肉毒中毒患者胃内容物中的B型蛋白水解肉毒梭菌
Foodborne Pathog Dis. 2004 Spring;1(1):53-7. doi: 10.1089/153531404772914464.
4
Differentiation of the gene clusters encoding botulinum neurotoxin type A complexes in Clostridium botulinum type A, Ab, and A(B) strains.A型、Ab型和A(B)型肉毒梭菌中编码A型肉毒杆菌神经毒素复合物的基因簇的分化
Appl Environ Microbiol. 2004 Dec;70(12):7192-9. doi: 10.1128/AEM.70.12.7192-7199.2004.
5
Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts.E型肉毒梭菌染色体神经毒素基因簇的进化：由其罕见的质粒携带对应物提供的证据
Genome Biol Evol. 2016 Mar 2;8(3):540-55. doi: 10.1093/gbe/evw017.
6
Botulinum neurotoxin-encoding plasmids can be conjugatively transferred to diverse clostridial strains.肉毒杆菌神经毒素编码质粒可以通过共轭转移到不同的梭状芽孢杆菌菌株中。
Sci Rep. 2018 Feb 15;8(1):3100. doi: 10.1038/s41598-018-21342-9.
7
Neurotoxin gene clusters in Clostridium botulinum type A strains: sequence comparison and evolutionary implications.A型肉毒梭菌菌株中的神经毒素基因簇：序列比较及进化意义
Curr Microbiol. 2003 May;46(5):345-52. doi: 10.1007/s00284-002-3851-1.
8
Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: a European ring trial study to evaluate a real-time PCR assay.建立食品、饲料和环境样品中检测和分型 A、B、E 和 F 型肉毒梭菌神经毒素产生菌的国际标准：评估实时 PCR 检测方法的欧洲环试研究。
Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S152-7. doi: 10.1016/j.ijfoodmicro.2011.02.001. Epub 2011 Feb 24.
9
Evidence that plasmid-borne botulinum neurotoxin type B genes are widespread among Clostridium botulinum serotype B strains.有证据表明，携带质粒的B型肉毒杆菌神经毒素基因在B型肉毒梭菌菌株中广泛存在。
PLoS One. 2009;4(3):e4829. doi: 10.1371/journal.pone.0004829. Epub 2009 Mar 16.
10
Plasmid encoded neurotoxin genes in Clostridium botulinum serotype A subtypes.A型肉毒梭菌亚型中的质粒编码神经毒素基因。
Biochem Biophys Res Commun. 2007 Sep 14;361(1):49-54. doi: 10.1016/j.bbrc.2007.06.166. Epub 2007 Jul 20.

引用本文的文献

1
Botulinum neurotoxin X lacks potency in mice and in human neurons.肉毒神经毒素 X 在小鼠和人神经元中没有效价。
mBio. 2024 Mar 13;15(3):e0310623. doi: 10.1128/mbio.03106-23. Epub 2024 Feb 13.
2
Clostridial Neurotoxins: Structure, Function and Implications to Other Bacterial Toxins.梭菌神经毒素：结构、功能及对其他细菌毒素的影响
Microorganisms. 2021 Oct 23;9(11):2206. doi: 10.3390/microorganisms9112206.
3
Virulence Plasmids of the Pathogenic Clostridia.致病性梭菌的毒力质粒。
Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0034-2018.
4
Novel Botulinum Neurotoxins: Exploring Underneath the Iceberg Tip.新型肉毒神经毒素：冰山一角之下的探索。
Toxins (Basel). 2018 May 10;10(5):190. doi: 10.3390/toxins10050190.
5
Impact of genomic diversity on food safety.基因组多样性对食品安全的影响。
Curr Opin Food Sci. 2016 Aug;10:52-59. doi: 10.1016/j.cofs.2016.09.006.
6
Implications of Genome-Based Discrimination between Clostridium botulinum Group I and Clostridium sporogenes Strains for Bacterial Taxonomy.基于基因组的肉毒梭菌I群与生孢梭菌菌株之间的差异对细菌分类学的影响
Appl Environ Microbiol. 2015 Aug 15;81(16):5420-9. doi: 10.1128/AEM.01159-15. Epub 2015 Jun 5.
7
Historical and current perspectives on Clostridium botulinum diversity.肉毒梭菌多样性的历史与当前观点
Res Microbiol. 2015 May;166(4):290-302. doi: 10.1016/j.resmic.2014.09.007. Epub 2014 Oct 12.
8
Complete nucleotide sequence of a plasmid containing the botulinum neurotoxin gene in Clostridium botulinum type B strain 111 isolated from an infant patient in Japan.从日本一名婴儿患者中分离到的 B 型肉毒梭菌 111 株携带的肉毒神经毒素基因的质粒的完整核苷酸序列。
Mol Genet Genomics. 2014 Dec;289(6):1267-74. doi: 10.1007/s00438-014-0887-4. Epub 2014 Aug 23.