B 型肉毒梭菌在连续传代过程中毒力稳定性的研究
Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.
机构信息
Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan.
出版信息
Microbiol Immunol. 2012 May;56(5):338-41. doi: 10.1111/j.1348-0421.2012.00441.x.
Abstract
Proteolytic Clostridium botulinum type B strains were investigated for stability of toxigenicity and bont/b gene upon serial passage. Strains with bont/b gene located on their plasmids showed loss or decrease of toxigenicity during serial passage. Some strains lost the bont/b gene-encoding plasmid. The stability of the plasmids varied between strains.
摘要
研究了具有蛋白水解活性的 B 型肉毒梭菌菌株在连续传代过程中毒力和 bont/b 基因的稳定性。带有位于质粒上的 bont/b 基因的菌株在连续传代过程中显示出毒力的丧失或降低。一些菌株丢失了编码 bont/b 基因的质粒。质粒的稳定性在菌株间有所不同。
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