Department of Neuropediatrics, Prof. Dr. A. Posadas Hospital, Buenos Aires, Argentina.
Pediatr Neurol. 2012 Mar;46(3):182-4. doi: 10.1016/j.pediatrneurol.2011.12.004.
Migrating focal seizures in infancy are an unusual and often overlooked epilepsy syndrome, with onset before age 6 months, in which nearly continuous seizures involve multiple, independent areas of both hemispheres with an arrest of psychomotor development. We describe a patient with migrating focal seizures in infancy whose seizures began at age 45 days. The seizures were refractory to common antiepileptic drugs. At age 6 months, the infant received potassium bromide and became almost seizure-free. The infant developed severe neurologic impairment, with marked axial hypotonia and an absence of visual contact and head control. At age 8 months, the child suddenly died. Pathologic findings included multiple malformations of cortical development, polymicrogyria, and focal cortical dysplasia associated with hippocampal sclerosis.
婴儿局灶性转移性癫痫是一种不常见且常被忽视的癫痫综合征，发病年龄在 6 个月之前，几乎持续不断的癫痫发作涉及两个半球的多个独立区域，伴有精神运动发育停滞。我们描述了一名婴儿局灶性转移性癫痫患者，其癫痫发作始于 45 天大时。该患者对常见的抗癫痫药物无反应。6 个月大时，婴儿开始服用溴化钾，几乎无癫痫发作。婴儿出现严重的神经功能障碍，表现为明显的轴向低张力，缺乏视觉接触和头部控制。8 个月大时，患儿突然死亡。病理发现包括皮质发育畸形、多微小脑回和局灶性皮质发育不良，伴有海马硬化。
