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恶性肝门部胆管梗阻双侧支架置入方法的比较

A comparison of bilateral stenting methods for malignant hilar biliary obstruction.

作者信息

Kim Kwang Min, Lee Kwang Hyuck, Chung Yun Hee, Shin Jae Uk, Lee Jong Kyun, Lee Kyu Taek, Shim Sang Goon

机构信息

Department of Medicine, Samsung Medical Center, Seoul, Korea.

出版信息

Hepatogastroenterology. 2012 Mar-Apr;59(114):341-6. doi: 10.5754/hge11533.

Abstract

BACKGROUND/AIMS: Despite common use of stent-instent methods for endoscopic bilateral metal stenting in malignant hilar obstruction, the longevity of these stents and clinical outcomes of patients who receive them are less well known than for the side-by-side method. We aimed to compare treatment outcomes according to bilateral stenting method.

METHODOLOGY

A total of 41 patients were divided into two groups: a bilateral side-by-side metal stenting group (side-by-side group, n=19) and a bilateral stent-in-stent metal stenting group (stent-in-stent group, n=22).

RESULTS

During the study period, successful drainage was achieved in 15 of 19 patients (78.9%) with the side-by-side placement, which did not differ significantly from the proportion with the stent-in-stent placement (18 of 22 patients, 81.8%). The two groups did not differ significantly in rates of early complications (31.6% vs. 22.7%, p=0.725), late complications (36.8% vs. 50.0%, p=0.531) or death (47.4% vs. 54.5%, p=0.647). Comparing stent patency and survival curves according to bilateral stenting type, patients with stent-in-stent placement and those with side-by-side placement did not differ significantly (p=0.771 and p=0.769).

CONCLUSIONS

Our results show no significant difference in clinical outcomes, including stent patency and overall survival, between side-by-side and stent-in-stent bilateral metal stenting in patients with malignant hilar obstruction.

摘要

背景/目的:尽管金属支架套入法在内镜下双侧金属支架置入治疗恶性肝门部梗阻中常用,但与并排法相比,这些支架的使用寿命以及接受这些支架治疗的患者的临床结局鲜为人知。我们旨在比较双侧支架置入方法的治疗效果。

方法

总共41例患者被分为两组:双侧并排金属支架置入组(并排组,n = 19)和双侧金属支架套入式支架置入组(支架套入组,n = 22)。

结果

在研究期间,并排放置的19例患者中有15例(78.9%)成功实现引流,这与支架套入式放置的比例(22例患者中的18例,81.8%)无显著差异。两组在早期并发症发生率(31.6% 对 22.7%,p = 0.725)、晚期并发症发生率(36.8% 对 50.0%,p = 0.531)或死亡率(47.4% 对 54.5%,p = 0.647)方面无显著差异。根据双侧支架置入类型比较支架通畅率和生存曲线,支架套入式放置的患者和并排放置的患者无显著差异(p = 0.771和p = 0.769)。

结论

我们的结果表明,在恶性肝门部梗阻患者中,并排和支架套入式双侧金属支架置入在包括支架通畅率和总生存率在内的临床结局方面无显著差异。

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