热休克蛋白（HSP）70-2基因型在日本人群消化性溃疡中的作用。

Role of heat-shock protein (HSP) 70-2 genotype in peptic ulcer in Japanese population.

作者信息

Tahara Tomomitsu, Arisawa Tomiyasu, Shibata Tomoyuki, Yamashita Hiromi, Nakamura Masakatsu, Yoshioka Daisuke, Okubo Masaaki, Maruyama Naoko, Kamano Toshiaki, Kamiya Yoshio, Fujita Hiroshi, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Nakano Hiroshi, Hirata Ichiro

机构信息

Department of Gastoenterology, Fujita Health University School of Medicine, Aichi, Japan.

出版信息

Hepatogastroenterology. 2012 Mar-Apr;59(114):426-9. doi: 10.5754/hge09606.

DOI:10.5754/hge09606

PMID:22353510

Abstract

BACKGROUND/AIMS: There have been reports showing the protective role of inducible heat-shock protein (HSP) 70 in gastric epithelial cells. An A to G transition at the 1267 position HSP70-2 gene has been shown to be associated with a different level of HSP70 mRNA expression. We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population.

METHODOLOGY

A total of 519 subjects participated in this study. All subjects underwent upper gastroscopy. Restriction fragment length polymorphism analysis was performed for polymorphisms at 1267 of HSP70-2 gene in all the subjects.

RESULTS

After gastroscopy, 109, 53 and 357 subjects were diagnosed as gastric ulcer, duodenal ulcer and non-ulcer subjects, respectively. Although, there were no significant differences of HSP70-2 genotype distributions among nonulcer subjects, overall ulcer, gastric and duodenal ulcers when the subjects were divided into two groups according to age distribution, logistic regression analysis showed that the BB genotype increased the risk of duodenal ulcer in subjects 60 years and older. (Gender, status of H. pylori infection and NSAID use adjusted OR=3.12, 95%CI=1.33-7.35, p=0.009).

CONCLUSIONS

It appears that polymorphism of HSP70-2 gene is not directly associated with the susceptibility to peptic ulcer diseases but BB genotype is associated with an increased risk of duodenal ulcer in older subjects in the Japanese population.

摘要

背景/目的：有报道显示诱导型热休克蛋白（HSP）70在胃上皮细胞中具有保护作用。已表明HSP70 - 2基因1267位的A到G转换与不同水平的HSP70 mRNA表达相关。我们旨在阐明HSP70 - 2基因多态性对日本人群消化性溃疡疾病风险的影响。

方法

共有519名受试者参与本研究。所有受试者均接受了上消化道内镜检查。对所有受试者的HSP70 - 2基因1267位的多态性进行了限制性片段长度多态性分析。

结果

胃镜检查后，分别有109名、53名和357名受试者被诊断为胃溃疡、十二指肠溃疡和非溃疡受试者。尽管根据年龄分布将受试者分为两组时，非溃疡受试者、总体溃疡患者、胃溃疡和十二指肠溃疡患者的HSP70 - 2基因型分布无显著差异，但逻辑回归分析显示，BB基因型增加了60岁及以上受试者患十二指肠溃疡的风险。（性别、幽门螺杆菌感染状况和非甾体抗炎药使用情况调整后的OR = 3.12，95%CI = 1.33 - 7.35，p = 0.009）。