Division of Geriatric Medicine, Hacettepe University, Ankara, Turkey.
Dement Geriatr Cogn Disord. 2012;33(1):6-10. doi: 10.1159/000336053. Epub 2012 Feb 18.
BACKGROUND/AIM: Dementia is one of the most common health problems in the world. Alzheimer's disease (AD) is the most common form of dementia. The relation between blood pressure (BP) and dementia has been the subject of numerous epidemiological studies, and midlife hypertension (HT) is a risk factor for AD. The association between BP and risk of dementia is lower in the older population. The aim of this study was to examine the association between the prevalence of HT and AD in elderly individuals.
In this cross-sectional study, 193 patients with AD and 1,860 patients with normal cognitive function were evaluated.
The prevalence of HT was lower in the AD group (60.6 vs. 70.5%; p = 0.005). In multivariate analysis, AD was found to be negatively correlated with HT (OR = 0.649; 95% CI 0.461-0.916).
The prevalence of HT was lower in patients with AD compared to subjects without AD. Physicians who deal with AD patients must keep in mind that the need for antihypertensive medication may decline during the dementia process.
背景/目的：痴呆是全球最常见的健康问题之一。阿尔茨海默病（AD）是最常见的痴呆类型。血压（BP）与痴呆之间的关系是许多流行病学研究的主题，中年高血压（HT）是 AD 的一个危险因素。在老年人群中，BP 与痴呆风险之间的关联较低。本研究旨在探讨老年人群中 HT 的患病率与 AD 之间的关系。
在这项横断面研究中，评估了 193 例 AD 患者和 1860 例认知功能正常的患者。
AD 组的 HT 患病率较低（60.6%比 70.5%；p=0.005）。多因素分析显示，AD 与 HT 呈负相关（OR=0.649；95%CI 0.461-0.916）。
与无 AD 的患者相比，AD 患者的 HT 患病率较低。处理 AD 患者的医生必须记住，在痴呆过程中，抗高血压药物的需求可能会下降。
