血管细胞黏附分子-1 在人结膜肿瘤中的免疫定位。
Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors.
机构信息
Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
出版信息
Ophthalmic Res. 2012;48(1):33-7. doi: 10.1159/000335983. Epub 2012 Feb 16.
OBJECTIVE
We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans.
METHODS
Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression.
RESULTS
Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels.
CONCLUSIONS
The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.
目的
分析血管黏附蛋白（VAP）-1 在人结膜肿瘤和正常结膜组织中的表达和免疫定位。
方法
通过免疫组织化学分析 9 种结膜肿瘤（包括化脓性肉芽肿和结外黏膜边缘区 B 细胞淋巴瘤）和 2 种正常结膜中 VAP-1 和 CD31 的表达。
结果
化脓性肉芽肿和结外黏膜边缘区 B 细胞淋巴瘤的微血管管腔中检测到 VAP-1 免疫反应性。相比之下，正常球结膜组织的血管中 VAP-1 细胞质免疫反应性较弱。
结论
VAP-1 的免疫定位在结膜组织病理学中存在差异，涉及炎症性结膜疾病的病理学。
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