• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

临床级[镓]Ga-DOTA-Siglec-9的放射性合成探索

Adventures in radiosynthesis of clinical grade [Ga]Ga-DOTA-Siglec-9.

作者信息

Käkelä Meeri, Luoto Pauliina, Viljanen Tapio, Virtanen Helena, Liljenbäck Heidi, Jalkanen Sirpa, Knuuti Juhani, Roivainen Anne, Li Xiang-Guo

机构信息

Turku PET Centre, University of Turku FI-20521 Turku Finland

Turku PET Centre, Turku University Hospital FI-20521 Turku Finland.

出版信息

RSC Adv. 2018 Feb 20;8(15):8051-8056. doi: 10.1039/c7ra12423f. eCollection 2018 Feb 19.

DOI:10.1039/c7ra12423f
PMID:35542034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078465/
Abstract

We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.

摘要

我们最终成功建立了一种用于生成符合药品生产质量管理规范（GMP）级别的镓-68标记的1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸缀合的含唾液酸结合免疫球蛋白样凝集素9基序的肽（[镓]Ga-DOTA-唾液酸结合免疫球蛋白样凝集素9）的方案，这是首个用于血管黏附蛋白1正电子发射断层扫描成像的放射性药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/092ca8c5c83f/c7ra12423f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/08857316084e/c7ra12423f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/5cbc0e92307a/c7ra12423f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/83a6366944bf/c7ra12423f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/eb85bd3e6114/c7ra12423f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/092ca8c5c83f/c7ra12423f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/08857316084e/c7ra12423f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/5cbc0e92307a/c7ra12423f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/83a6366944bf/c7ra12423f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/eb85bd3e6114/c7ra12423f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c874/9078465/092ca8c5c83f/c7ra12423f-f4.jpg

相似文献

1
Adventures in radiosynthesis of clinical grade [Ga]Ga-DOTA-Siglec-9.临床级[镓]Ga-DOTA-Siglec-9的放射性合成探索
RSC Adv. 2018 Feb 20;8(15):8051-8056. doi: 10.1039/c7ra12423f. eCollection 2018 Feb 19.
2
Exploring the radiosynthesis and in vitro characteristics of [ Ga]Ga-DOTA-Siglec-9.探索[镓]镓-DOTA-唾液酸结合免疫球蛋白样凝集素-9的放射性合成及体外特性。
J Labelled Comp Radiopharm. 2017 Jul;60(9):439-449. doi: 10.1002/jlcr.3525. Epub 2017 Jun 21.
3
Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis.针对自身免疫性心肌炎的血管黏附蛋白-1 靶向 PET 成像。
J Nucl Cardiol. 2023 Dec;30(6):2760-2772. doi: 10.1007/s12350-023-03371-8. Epub 2023 Sep 27.
4
Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [Ga]Ga- and [F]AlF-NOTA-Siglec-9.探索唾液酸结合免疫球蛋白样凝集素 9 肽的替代放射性标记策略：[Ga]Ga-和[F]AlF-NOTA-Siglec-9。
Molecules. 2018 Jan 31;23(2):305. doi: 10.3390/molecules23020305.
5
(68)Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections.（68）镓-多胺多羧基大环配体-唾液酸结合免疫球蛋白样凝集素9正电子发射断层显像/计算机断层扫描成像观察种植体周围组织反应及葡萄球菌感染情况
EJNMMI Res. 2014 Aug 8;4:45. doi: 10.1186/s13550-014-0045-3. eCollection 2014.
6
Comparison of Ga-DOTA-Siglec-9 and F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.镓-DOTA-Siglec-9 与 F-氟代脱氧核糖-Siglec-9 的比较：炎症成像和辐射剂量学。
Contrast Media Mol Imaging. 2017 Dec 31;2017:7645070. doi: 10.1155/2017/7645070. eCollection 2017.
7
68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.68Ga-DOTA-唾液酸结合免疫球蛋白样凝集素9——一种检测滑膜炎的新型成像工具。
Arthritis Res Ther. 2015 Nov 3;17:308. doi: 10.1186/s13075-015-0826-8.
8
Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.（68）镓标记的唾液酸结合免疫球蛋白样凝集素-9肽用于急性肺炎症成像的可行性：急性呼吸窘迫综合征猪模型的初步研究
Am J Nucl Med Mol Imaging. 2016 Jan 28;6(1):18-31. eCollection 2016.
9
Kinetic Modelling of [Ga]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections.[Ga]Ga-DOTA-Siglec-9 在猪骨髓炎和软组织感染中的动力学建模。
Molecules. 2019 Nov 13;24(22):4094. doi: 10.3390/molecules24224094.
10
Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.正电子发射断层扫描通过靶向血管黏附蛋白-1 来可视化感染伯氏疏螺旋体的小鼠中的炎症部位。
Arthritis Res Ther. 2017 Nov 22;19(1):254. doi: 10.1186/s13075-017-1460-4.

引用本文的文献

1
Investigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability.镓（III）与硫脲衍生物配合物的研究：pH对配位和稳定性的影响
Int J Mol Sci. 2024 Nov 29;25(23):12869. doi: 10.3390/ijms252312869.
2
Radiosynthesis, structural identification and in vitro tissue binding study of [F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3.新型放射性肽[F]FNA-S-ACooP的放射性合成、结构鉴定及体外组织结合研究，用于脂肪酸结合蛋白3的靶向正电子发射断层显像（PET）成像
EJNMMI Radiopharm Chem. 2024 Feb 23;9(1):16. doi: 10.1186/s41181-024-00245-3.
3
New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation.

本文引用的文献

1
Position paper on requirements for toxicological studies in the specific case of radiopharmaceuticals.放射性药物特殊情况下毒理学研究要求的立场文件。
EJNMMI Radiopharm Chem. 2017;1(1):1. doi: 10.1186/s41181-016-0004-6. Epub 2016 Mar 21.
2
Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.正电子发射断层扫描通过靶向血管黏附蛋白-1 来可视化感染伯氏疏螺旋体的小鼠中的炎症部位。
Arthritis Res Ther. 2017 Nov 22;19(1):254. doi: 10.1186/s13075-017-1460-4.
3
Head-to-Head Comparison of Ga-Citrate and F-FDG PET/CT for Detection of Infectious Foci in Patients with Bacteraemia.
新型稳定的镓（III）和铟（III）与硫代氨基脲配体的配合物：生物学评价。
Molecules. 2024 Jan 19;29(2):497. doi: 10.3390/molecules29020497.
4
Ga-Citrate PET of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates.镓-柠檬酸 PET 健康男性全身：生物分布动力学和辐射剂量估算。
J Nucl Med. 2022 Oct;63(10):1598-1603. doi: 10.2967/jnumed.122.263884. Epub 2022 Mar 10.
5
First-in-Humans Study of Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.人类首个人体研究：Ga-DOTA-Siglec-9，一种靶向血管黏附蛋白 1 的 PET 配体。
J Nucl Med. 2021 Apr;62(4):577-583. doi: 10.2967/jnumed.120.250696. Epub 2020 Aug 17.
6
Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats.DOTA-Siglec-9 肽单次静脉给药在 Sprague Dawley 大鼠中的安全性研究。
Int J Toxicol. 2019 Jan/Feb;38(1):4-11. doi: 10.1177/1091581818821606. Epub 2019 Jan 20.
头对头比较枸橼酸镓和 F-FDG PET/CT 检测菌血症患者感染病灶。
Contrast Media Mol Imaging. 2017 Oct 17;2017:3179607. doi: 10.1155/2017/3179607. eCollection 2017.
4
Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation.血管黏附蛋白-1：翻译中的细胞表面胺氧化酶。
Antioxid Redox Signal. 2019 Jan 20;30(3):314-332. doi: 10.1089/ars.2017.7418. Epub 2017 Dec 7.
5
Exploring the radiosynthesis and in vitro characteristics of [ Ga]Ga-DOTA-Siglec-9.探索[镓]镓-DOTA-唾液酸结合免疫球蛋白样凝集素-9的放射性合成及体外特性。
J Labelled Comp Radiopharm. 2017 Jul;60(9):439-449. doi: 10.1002/jlcr.3525. Epub 2017 Jun 21.
6
Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.白细胞转运相关血管粘附蛋白1在动脉粥样硬化斑块中表达且具有功能活性。
Sci Rep. 2016 Oct 12;6:35089. doi: 10.1038/srep35089.
7
(18)F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography.用于炎症研究的正电子发射断层显像的甘露聚糖F标记
ACS Med Chem Lett. 2016 May 16;7(9):826-30. doi: 10.1021/acsmedchemlett.6b00160. eCollection 2016 Sep 8.
8
Radiolabeling of DOTA-like conjugated peptides with generator-produced (68)Ga and using NaCl-based cationic elution method.用发生器产生的（68）Ga对类DOTA共轭肽进行放射性标记，并采用基于氯化钠的阳离子洗脱方法。
Nat Protoc. 2016 Jun;11(6):1057-66. doi: 10.1038/nprot.2016.060. Epub 2016 May 12.
9
Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.（68）镓标记的唾液酸结合免疫球蛋白样凝集素-9肽用于急性肺炎症成像的可行性：急性呼吸窘迫综合征猪模型的初步研究
Am J Nucl Med Mol Imaging. 2016 Jan 28;6(1):18-31. eCollection 2016.
10
Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes.血清血管黏附蛋白-1可预测2型糖尿病患者的终末期肾病
PLoS One. 2016 Feb 4;11(2):e0147981. doi: 10.1371/journal.pone.0147981. eCollection 2016.