临床级[镓]Ga-DOTA-Siglec-9的放射性合成探索
Adventures in radiosynthesis of clinical grade [Ga]Ga-DOTA-Siglec-9.
作者信息
Käkelä Meeri, Luoto Pauliina, Viljanen Tapio, Virtanen Helena, Liljenbäck Heidi, Jalkanen Sirpa, Knuuti Juhani, Roivainen Anne, Li Xiang-Guo
机构信息
Turku PET Centre, University of Turku FI-20521 Turku Finland
Turku PET Centre, Turku University Hospital FI-20521 Turku Finland.
出版信息
RSC Adv. 2018 Feb 20;8(15):8051-8056. doi: 10.1039/c7ra12423f. eCollection 2018 Feb 19.
We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.
我们最终成功建立了一种用于生成符合药品生产质量管理规范（GMP）级别的镓-68标记的1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸缀合的含唾液酸结合免疫球蛋白样凝集素9基序的肽（[镓]Ga-DOTA-唾液酸结合免疫球蛋白样凝集素9）的方案，这是首个用于血管黏附蛋白1正电子发射断层扫描成像的放射性药物。
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