(+)-安纳马里宁的全合成。

Total synthesis of (+)-anamarine.

机构信息

Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, A.P., India.

出版信息

Org Biomol Chem. 2012 Apr 7;10(13):2647-55. doi: 10.1039/c2ob06940g. Epub 2012 Feb 22.

Abstract

Total synthesis of (+)-anamarine a polyoxygenated δ-pyranone natural product was accomplished via cross-metathesis protocol starting from 3-butene-1-ol and glycidol. Other key features of this synthetic strategy include use of Sharpless asymmetric epoxidation, dihydroxylation, and deoxygenation-isomerization through allene rearrangement.

摘要

通过从 3-丁烯-1-醇和缩水甘油开始的交叉复分解协议，完成了 (+)-anamarine 一种多氧化 δ-吡喃酮天然产物的全合成。该合成策略的其他关键特征包括使用 Sharpless 不对称环氧化、二羟基化和通过丙二烯重排进行脱氧-异构化。