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One step from prediabetes to diabetes: hypothalamic inflammation?

作者信息

Cai Dongsheng

机构信息

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

出版信息

Endocrinology. 2012 Mar;153(3):1010-3. doi: 10.1210/en.2011-2183.

DOI:10.1210/en.2011-2183
PMID:22355177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3281529/
Abstract
摘要

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本文引用的文献

1
Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.非糖尿病 IRS2-/- 小鼠和糖尿病 IRS2-/- 小鼠中神经肽 Y 和 proopiomelanocortin 表达的差异胰岛素受体底物 1（IRS1）相关调节。
Endocrinology. 2012 Mar;153(3):1129-40. doi: 10.1210/en.2011-1278. Epub 2011 Dec 30.
2
Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway.下丘脑自噬缺陷通过 IkappaB 激酶β（IKKβ）/NF-κB 通路指导肥胖的中枢发病机制。
J Biol Chem. 2011 Sep 16;286(37):32324-32. doi: 10.1074/jbc.M111.254417. Epub 2011 Jul 22.
3
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB.通过靶向下丘脑 IKK-β 和 NF-κB 来解耦肥胖和高血压的机制。
Nat Med. 2011 Jun 5;17(7):883-7. doi: 10.1038/nm.2372.
4
Inflammatory links between obesity and metabolic disease.肥胖与代谢性疾病之间的炎症关联。
J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1.
5
A role for astrocytes in the central control of metabolism.星形胶质细胞在代谢的中枢控制中的作用。
Neuroendocrinology. 2011;93(3):143-9. doi: 10.1159/000324888. Epub 2011 Mar 4.
6
Study on establishment of congenic strains and screening of characteristics in IRS-2 deficient mice to support translational research on type 2 diabetes.建立 IRS-2 缺陷小鼠同源系及筛选特征品系以支持 2 型糖尿病转化研究
Exp Anim. 2011;60(1):21-32. doi: 10.1538/expanim.60.21.
7
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.神经肽胞吐涉及突触结合蛋白-4 和催产素在下丘脑体重和能量平衡编程中的作用。
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Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.JNK1 在代谢调节中的作用：下丘脑-垂体-甲状腺轴。
Genes Dev. 2010 Feb 1;24(3):256-64. doi: 10.1101/gad.1878510. Epub 2010 Jan 15.