School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM, Bangi, Selangor, Malaysia.
Sci Rep. 2011;1:71. doi: 10.1038/srep00071. Epub 2011 Aug 23.
The phase behaviour of a system composed of amino acid-based surfactant (sodium N-lauroylsarcosinate hydrate), 1-decanol and deionised water was investigated for vesicle formation. Changing the molar ratio of the amphiphiles, two important aggregate structures were observed in the aqueous corner of the phase diagram. Two different sizes of microemulsions were found at two amphiphile-water boundaries. A stable single vesicle lobe was found for 1∶2 molar ratios in 92 wt% water with vesicles approximately 100 nm in size and with high zeta potential value. Structural variation arises due to the reduction of electrostatic repulsions among the ionic headgroups of the surfactants and the hydration forces due to adsorbed water onto monolayer's. The balance of these two forces determines the aggregate structures. Analysis was followed by the molecular geometrical structure. These findings may have implications for the development of drug delivery systems for cancer treatments, as well as cosmetic and food formulations.
该系统的相行为组成的氨基酸基表面活性剂(水合 N-月桂酰肌氨酸钠),1-癸醇和去离子水进行了研究囊泡形成。改变两亲物的摩尔比，在相图的水相区观察到两种重要的聚集结构。在两个两亲物-水边界处发现了两种不同大小的微乳液。在 92wt%的水中，当摩尔比为 1∶2 时，得到了稳定的单囊泡叶，囊泡的尺寸约为 100nm，具有较高的 zeta 电位值。结构的变化源于减少了离子表面活性剂头基之间的静电排斥和由于吸附在单层上的水产生的水化力。这两种力的平衡决定了聚集结构。通过分子几何结构进行了分析。这些发现可能对癌症治疗药物输送系统的开发以及化妆品和食品制剂具有重要意义。
