Ashraf Tariq, Memon Muhammad Anis, Talpur Muhammad Saeed, Panhwar Ziauddin, Rasool Syed Ishtiaq
Department of Cardiology, National Institute of Cardiovascular Disease, Karachi.
J Pak Med Assoc. 2011 Aug;61(8):729-32.
To evaluate the frequency of metabolic syndrome in patients with Ischaemic Heart Disease.
This was a cross sectional observational study. Patients with a first time cardiac event arriving in emergency room during the period October 2009 to April 2010, were included. Five components of Metabolic syndrome were defined according to criteria set by International Diabetes Federation, American Heart Association & National Heart, Lung and Blood Institute which had abdominal obesity (waist circumference) as an integral part of the syndrome. Blood sugar, triglycerides, HDL-C were measured within 24 hrs of cardiac insult. Hypertension was defined as blood pressure > 130/85 mmHg. Variables were integrated for descriptive statistics.
A total of 477 patients diagnosed with Ischaemic Heart Disease were inducted in the study. There were 355 (74%) males and 122 (26%) females. Frequency of metabolic syndrome in Ischaemic heart disease was seen in 195 (54.95%) males and 96 (78.7%) females (p < 0.001). According to recent criteria abdominal obesity was observed in 91 (81.1%) females as compared to males 219 (61.7%) (p < 0.001) Similarly, low HDL and Hypertension were high in frequency in females. No significant difference in triglycerides levels was found in either gender.
Frequency of metabolic syndrome with Ischaemic heart disease was high in females as compared to males. This could be attributed to the increased prevalence of abdominal obesity.
评估缺血性心脏病患者代谢综合征的发生率。
这是一项横断面观察性研究。纳入2009年10月至2010年4月期间首次因心脏事件抵达急诊室的患者。根据国际糖尿病联盟、美国心脏协会及美国国立心肺血液研究所制定的标准定义代谢综合征的五个组成部分，该标准将腹型肥胖（腰围）作为综合征的一个组成部分。在心脏损伤后24小时内测量血糖、甘油三酯、高密度脂蛋白胆固醇。高血压定义为血压>130/85 mmHg。对变量进行整合以进行描述性统计。
本研究共纳入477例诊断为缺血性心脏病的患者。其中男性355例（74%），女性122例（26%）。缺血性心脏病患者中，男性代谢综合征的发生率为195例（54.95%），女性为96例（78.7%）（p<0.001）。根据最新标准，女性腹型肥胖的发生率为91例（81.1%），男性为219例（61.7%）（p<0.001）。同样，女性高密度脂蛋白水平低和高血压的发生率较高。两性之间甘油三酯水平无显著差异。
与男性相比，缺血性心脏病患者中女性代谢综合征的发生率较高。这可能归因于腹型肥胖患病率的增加。
