重型β地中海贫血患者脾切除与门静脉血栓形成的相关性

Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major.

作者信息

Hassan Mahmoodi Nesheli, Tahereb Galini Moghaddam, Ahmad Tamaddoni, Asghar Darzi Ali, Reza Esmaeili Dooki Mohammad, Ali Bijani, Mohsen Mahmoodi Nesheli

机构信息

Department of Pediatric Hematology & Oncology, Babol University of Medical Sciences, Babol, Iran.

出版信息

J Pak Med Assoc. 2011 Aug;61(8):760-2.

PMID:22355997

Abstract

OBJECTIVE

To evaluate the correlation of portal vein thrombosis and splenectomy in beta-thalassemia major patients visiting Babol Medical University, Iran.

METHODS

This cohort study was done from 1997 to 2008. In our study, major beta-thalassemic patients visiting for transfusion at least once a month at Amirkola Children's Hospital were selected. Portal vein thrombosis was diagnosed through Doppler ultrasound in symptomatic patients. Cases were 160 beta-thalassemia major patients who underwent splenectomy and 160 remaining thalassemic patients without splenectomy were controls. Statistical comparison with Fisher exact test was performed.

RESULTS

Five cases had suffered from portal vein thrombosis (P = 0.03). Majority patients with portal vein thrombosis had their symptoms after first month of the operation.

CONCLUSION

Correlation of splenectomy with portal vein thrombosis is statistically significant among beta-thalassemic children from Iran.

摘要

目的

评估伊朗巴博勒医科大学就诊的重型β地中海贫血患者门静脉血栓形成与脾切除术之间的相关性。

方法

本队列研究于1997年至2008年进行。在我们的研究中，选取了在阿米科拉儿童医院每月至少输血一次的重型β地中海贫血患者。有症状的患者通过多普勒超声诊断门静脉血栓形成。病例为160例行脾切除术的重型β地中海贫血患者，160例未行脾切除术的其余地中海贫血患者作为对照。采用Fisher精确检验进行统计学比较。